scleroderma
The disease can be either localized to the skin or involve other organs as well. In patients with scleroderma the immune system triggers other cells to produce too much collagen a protein.
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Scleroderma is an autoimmune rheumatic and chronic disease that affects the body by hardening connective tissue.
. Skin color changes The patches of hardened skin can be lighter or darker than your natural skin color. Scleroderma sklair-oh-DUR-muh is a group of rare diseases that involve the hardening and tightening of the skin and connective tissues. Connective tissue is widespread.
A connective tissue disease is one that affects tissues such as skin tendons and cartilage. Scleroderma involves many systems in your body. However the relative proportions of Type I and Type III collagen appear similar to those of normal adult dermis 7.
While there is no cure for scleroderma a variety of treatments can ease symptoms and improve quality of life. Tissue culture and enzyme studies indicate increased fibroblastie activity and collagen production during the active state of scleroderma 5 6. Scleroderma causes extremely dry skin and dry skin itches.
It happens when your immune system causes your body to make too much of the protein collagen. Scleroderma affects women more often than men and most commonly occurs between the ages of 30 and 50. Normally the immune system helps defend the body against disease and infection.
Scleroderma probably is both a vascular disease and an autoimmune disorder 4. Scleroderma is an autoimmune connective tissue and rheumatic disease that causes inflammation in the skin and other areas of the body. Scleroderma is a chronic although rare autoimmune disease in which normal tissue is replaced with dense thick fibrous tissue.
Scleroderma or systemic sclerosis is a chronic connective tissue disease generally classified as one of the autoimmune rheumatic diseases. Scleroderma literally means hard skin. Systemic sclerosis is also called scleroderma progressive systemic sclerosis or CREST syndrome.
Some people develop violet-colored skin which means that the scleroderma is active and expanding. Among them is collagen of the skin. Scleroderma is a group of autoimmune diseases that may result in changes to the skin blood vessels muscles and internal organs.
Symptoms may include areas of thickened skin stiffness feeling tired and poor blood flow to the fingers or toes with cold exposure. The extreme dryness can cause the skin to breakdown and sores can form. This inflammation leads to patches of tight hard skin.
The word scleroderma comes from the Greek word sclero meaning hard and the Latin word derma meaning skin. Scleroderma is a long-lasting disease that affects your skin connective tissue and internal organs. It adds strength to organs and other parts of the body Connective tissue is made of many kinds of proteins.
Calcinosis Raynauds phenomenon esophageal.
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